combipara-t

Trinity for more Powerful Relief

Aceclofenac 100 mg + Paracetamol 325 mg + Thiocolchicoside 4 mg

Low Back Pain, Joint pain & OA

1Tab BID

1x10

Aceclofenac: Aceclofenac is an NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory cascade. The COX-1 enzyme is a constitutive enzyme involved in prostacyclin production and protective functions of gastric mucosa whereas COX-2 is an inducible enzyme involved in the production of inflammatory mediators in response to inflammatory stimuli. Aceclofenac displays more selectivity towards COX-2 than COX-1, which promotes its gastric tolerance compared to other NSAIDs.

Paracetamol (Acetaminophen): Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory effects.

Thiocolchicoside: Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent.

It should be stored at room temperature away from light.

Lorpiprazole, Acenocoumarol, Acemetacin, Acebutolol etc.

Lorpiprazole, Acenocoumarol, Acemetacin, Acebutolol etc.