Topical Solution For Pain Free Life
Lidocaine Hydrocloride IP 5.00% w/w Gabapentin USP 6.00% w/w Methylparaben IP 0.10% w/w Propylparaben IP 0.05%w/w Gel Base q.s.
In Management of Pain due to post Herpetic neuralgia, Diabetic neuropathy.
To be applied topically 3 times a day
Lidocaine alters signal conduction in neurons by blocking the fast voltage-gated Na+ channels in the neuronal cell membrane responsible for signal propagation. With sufficient blockage, the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential.
Gabapentin interacts with a high-affinity binding site in brain membranes, which has recently been identified as an auxiliary subunit of voltage-sensitive Ca2+ channels.
It should be stored at room temperature away from light